[An experimental study of sulprostone as an agent in preparation for abortion]. / Eksperimental'noe issledovanie sul'prostona kak sredstva podgotovki k abortu.

The prostaglandin E sulprostone was studied in experiments on pregnant rats. It was shown to stimulate the bioelectrical activity of the uterus, by increasing the amplitude and frequency of biological potentials. Sulprostone was found to have abortive and embryotoxic effects which were especially pronounced during placentation. The drug induced a slight teratogenic effect.

[Effect of a new prostaglandin aroxaprostol on the contractile activity of the uterus and its abortive action in experimental studies]. / Vliianie novogo prostaglandina aroksaprostola na sokratitel'nuiu aktivnost' matki i ego abortivnyi éffekt v éksperimente.

Experiments with pregnant and nonpregnant rats have shown that aroxaprostol, a group F2 alpha prostaglandin, injected intravenously and intramuscularly in a dose of 50 micrograms/kg, stimulates the uterine bioelectric activity, increasing both the amplitude and frequency of biopotentials, this evidencing intensification of its contractility. Aroxaprostol has shown an abortive effect, that was related to the luteolytic effect of the drug, manifesting by reduction of progesterone level in the ovaries.

[The contraceptive activity of triterpene glycosides--the total sum of holotoxins A1 and B1 and holothurin A in an experiment]. / Kontratseptivnaia aktivnost' triterpenovykh glikozidov--summy golotoksina A1 i B1 i goloturina A v éksperimente.

The sum of triterpene glycosides of the Far Eastern holothurian Stichopus japonicus Selenka (holotoxins A1 and B1) possesses the contraceptive activity. Glycoside holoturin A of the tropical holothurian Holoturia atra lacks these properties. The action of the sum of holotoxins is based on the estrogenic activity which was demonstrated both in the uterotropic and vaginotropic tests. The drug under study suppresses ovulation and stimulates the contractile activity of the uterus.

[The effect of oxytocin, prostenon and obzidan on uterine contractile activity in pregnant rats]. / Vliianie oksitotsina, prostenona i obzidana na sokratitel'nuiu aktivnost' matki beremennykh krys.

The results of experimental pharmacological studies may help obstetricians to make a choice of a schedule of using the uterotropic drugs and their doses. In vivo and in vitro experiments on pregnant rats showed that administration of the Soviet-made prostaglandin E2--prostenon--in combination with oxytocin and obsidan in half doses increased its stimulating effect on the myometrium. The use of prostenon and oxytocin against the background of partusisten treatment was not followed by a significant change of their stimulating uterotropic action.

[The combined and separate use of prostaglandin and adrenergic agents for the purpose of the experimental correction of uterine contractile activity]. / Sochetannoe i razdel'noe primenenie prostaglandina i adrenergicheskikh sredstv s tsel'iu korrektsii sokratitel'noi deiatel'nosti matki v éksperimente.

Experiments on pregnant rats revealed that a combination of low doses of partusisten and clophelin (1.25 mg/kg and 0.15 ml of 0.001% solution, respectively) potentiated a tocolytic effect. A combination of prostenon and oxytocin given in half doses (0.15 mg/kg and 0.25 IU in 0.1 ml, respectively) summarized their stimulant effect on the myometrium. Premedication with partusisten (2.5 micrograms/kg) failed to change the stimulant effect produced by a combination of prostenon and oxytocin given in half doses.

[Mechanism of the contraceptive action of the triterpene glycosides from the rock jasmine Androsace septentrionalis L]. / K mekhanizmu protivozachatochnogo deistviia triterpenovykh glikozidov prolomnika severnogo.

The sum of triterpene glycosides of Androsace septentrionalis L. (a plant of genus Primula) was shown to change the concentrations of lutropin and follitropin in the hypophysis and plasma and the ratio of these hormones in the blood plasma in the active phase of the cycle. This leads to the change of the ovarian hormonal activity in the direction of predominance of the estrogenic action and an increase of the uterine contractile activity that can be of certain significance in manifestation of the contraceptive effect.

[Contraceptive preparations of plant origin]. / Kontratseptivnye preparaty rastitel'nogo proiskhozhdeniia.

PIP: Studies on contraceptives of plant origin are important because the synthetic hormonal contraceptives in current use produce some side effects. Records on folk medicine mention 225 species of plants with contraceptive and abortive properties. However, experiments performed on animals have confirmed the contraceptive effect in only 145 of these plant species. Chemically, these drugs belong to a wide variety of classes including terpenoids, alkaloids, glycosides, phenols, and other compounds. The available literature on these compounds and their contraceptive effects is reviewed. The review indicates that a wide variety of plants with contraceptive properties can be found in the USR. However, many of these plants cannot be recommended for practical use due to a lack of complete pharmacological data. Further research is needed to find reliable contraceptives derived from plants that do not produce any side effects. Such contraceptives would be especially useful in those cases where hormonal contraceptive agents are contraindicated.^ieng

[Effect of cyngal on gastric secretion in rats]. / K kharakteristike vliianiia tsingala na zheludochnuiu sekretsiiu krys.

The authors studied the influence of gallic salt of cynoglossophin-heliosupin alkaloid (cyngal), extracted from Cynoglossum officinale L. on the gastric secretion of rats. Cyngal proved to stimulate the secretory function of the rat stomach, beginning from the dose of 0.25 mg/kg. This action is explained by the capacity of the preparation to release histamine from the labile depot.

[Possible pharmacologic regulation of the motor activity of the gastrointestinal tract]. / O vozmozhnostiakh farmakologicheskoi reguliatsii motornoi deiatel'nosti pishchevaritel'nogo apparata.

The authors present the results of pharmacological study of the effects of gallic salt cynoglossofin-geliosupin alkaloid (cyngal), isolated from the Cynoglossum officinale, on the gastrointestinal motor activity. A high stimulating activity of this preparation both in acute and chronic experiments on dogs was shown by using the balloon and electrographic recording technique. The ability of cyngal to release serotonin from the bound state can account for the gastrointestinal motor function stimulation.